Cognitive Function Deficits Associated With Long-Duration Type 1 Diabetes and Vascular Complications.

ABSTRACT:

Objective

Patients with type 1 diabetes now live long enough to experience cognitive decline. During middle age, they show mild cognitive deficits, but it is unknown whether severity increases with aging or whether cognitive profiles are similar to those of age-matched peers with and without diabetes.

Research design and methods

We tested and compared cognition in 82 individuals with 50 or more years of type 1 diabetes (Medalists), 31 age-matched individuals with type 2 diabetes, and 30 age-matched control subjects without diabetes. Medical histories and biospecimens were collected. We also evaluated the association of complications with cognition in Medalists only.

Results

Compared with control subjects, both individuals with type 1 diabetes and individuals with type

SUBMITTER: Musen G 

PROVIDER: S-EPMC6054500 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature