Diabetes and Trajectories of Estimated Glomerular Filtration Rate: A Prospective Cohort Analysis of the Atherosclerosis Risk in Communities Study.

ABSTRACT:

Objective

To characterize long-term kidney disease trajectories in persons with and without diabetes in a general population.

Research design and methods

We classified 15,517 participants in the community-based Atherosclerosis Risk in Communities (ARIC) study by diabetes status at baseline (1987-1989; no diabetes, undiagnosed diabetes, and diagnosed diabetes). We used linear mixed models with random intercepts and slopes to quantify estimated glomerular filtration rate (eGFR) trajectories at four visits over 26 years.

Results

Adjusted mean eGFR decline over the full study period among participants without diabetes was -1.4 mL/min/1.73 m²/year (95% CI -1.5 to -1.4), with undiagnosed diabetes was -1.8 mL/min/1.73 m²/year (95% CI -2.0 to -1.7) (diff

SUBMITTER: Warren B 

PROVIDER: S-EPMC6054502 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature