Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis.

ABSTRACT:

Background & aims

The degree of cholestasis is an important disease driver in alcoholic hepatitis, a severe clinical condition that needs new biomarkers and targeted therapies. We aimed to identify the largely unknown mechanisms and biomarkers linked to cholestasis in alcoholic hepatitis.

Methods

Herein, we analyzed a well characterized cohort of patients with alcoholic hepatitis and correlated clinical and histological parameters and outcomes with serum bile acids and fibroblast growth factor 19 (FGF19), a major regulator of bile acid synthesis.

Results

We found that total and conjugated bile acids were significantly increased in patients with alcoholic hepatitis compared with controls. Serum FGF19 levels were strongly increased and gene expression of FGF19 was induc

SUBMITTER: Brandl K 

PROVIDER: S-EPMC6054564 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature