Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks.

ABSTRACT:

Backgound

Alcohol use disorder (AUD) is devastating and poorly treated, and innovative targets are actively sought for prevention and treatment. The orphan G protein-coupled receptor GPR88 is enriched in mesocorticolimbic pathways, and Gpr88 knockout mice show hyperactivity and risk-taking behavior, but a potential role for this receptor in drug abuse has not been examined.

Methods

We tested Gpr88 knockout mice for alcohol-drinking and -seeking behaviors. To gain system-level understanding of their alcohol endophenotype, we also analyzed whole-brain functional connectivity in naïve mice using resting-state functional magnetic resonance imaging.

Results

Gpr88 knockout mice showed increased voluntary alcohol drinking at both moderate and excessive levels, with intact al

SUBMITTER: Ben Hamida S 

PROVIDER: S-EPMC6054571 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature