Cadmium exposure increases the risk of juvenile obesity: a human and zebrafish comparative study.

ABSTRACT:

Objective

Human obesity is a complex metabolic disorder disproportionately affecting people of lower socioeconomic strata, and ethnic minorities, especially African Americans and Hispanics. Although genetic predisposition and a positive energy balance are implicated in obesity, these factors alone do not account for the excess prevalence of obesity in lower socioeconomic populations. Therefore, environmental factors, including exposure to pesticides, heavy metals, and other contaminants, are agents widely suspected to have obesogenic activity, and they also are spatially correlated with lower socioeconomic status. Our study investigates the causal relationship between exposure to the heavy metal, cadmium (Cd), and obesity in a cohort of children and in a zebrafish model of adipogen

SUBMITTER: Green AJ 

PROVIDER: S-EPMC6054604 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature