Interaction between porous silica gel microcarriers and peptides for oral administration of functional peptides.

ABSTRACT: Functional peptides, peptides that have biological activities, have attracted attention as active ingredients of functional foods and health foods. In particular, for food applications, because orally ingested peptides are degraded by digestive enzymes in the stomach, novel oral administration methods that can prevent peptide degradation and successfully deliver them intestinally are desired. In the present study, we focused on porous silica gel, which has many useful characteristics, such as large surface area, pH responsive functional groups, size controllable pores, and approval as food additives. We investigated the possibility of using porous silica gel as a peptide degradation protective microcarrier. As a result, we found that heat treatment of the silica gel at 600 °C for 2 h remar

SUBMITTER: Imai K 

PROVIDER: S-EPMC6054636 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature