Renal sodium and magnesium reabsorption are not coupled in a mouse model of Gordon syndrome.

ABSTRACT: Active reabsorption of magnesium (Mg²⁺ ) in the distal convoluted tubule (DCT) of the kidney is crucial for maintaining Mg²⁺ homeostasis. Impaired activity of the Na⁺ -Cl^- -cotransporter (NCC) has been associated with hypermagnesiuria and hypomagnesemia, while increased activity of NCC, as observed in patients with Gordon syndrome, is not associated with alterations in Mg²⁺ balance. To further elucidate the possible interrelationship between NCC activity and renal Mg²⁺ handling, plasma Mg²⁺ levels and urinary excretion of sodium (Na⁺ ) and Mg²⁺ were measured in a mouse model of Gordon syndrome. In this model, DCT1-specific expression of a constitutively active mutant form of the NCC-phosphory

SUBMITTER: van Megen WH 

PROVIDER: S-EPMC6054696 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature