The burden of congenital hyperinsulinism in the United Kingdom: a cost of illness study.

ABSTRACT:

Background

Congenital hyperinsulinism (CHI) is a rare, genetic disease which causes persistent hypoglycaemia, typically in new-borns. Patients with the diffuse disease variant often require near-total surgical removal of the pancreas, causing insulin-dependent diabetes mellitus (IDDM). The CHI economic burden is currently unknown. This study aimed to estimate the annual cost of illness (COI) of CHI patients in the UK from a service provider perspective (National Health Service, NHS and Personal Social Services), and to explore cost distribution within the patient population.

Methods

The model was based on standard practice of two CHI centres of excellence. Model inputs were informed by a pragmatic literature review, NHS Reference Costs (2015-2016) and the British National Fo

SUBMITTER: Eljamel S 

PROVIDER: S-EPMC6054726 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature