Screening and identification of a six-cytokine biosignature for detecting TB infection and discriminating active from latent TB.

ABSTRACT:

Background

The early and accurate diagnosis of tuberculosis (TB) is critical for controlling the global TB epidemic. Although early studies have supported the potential role of cytokine biomarkers in blood for the diagnosis of TB, this method requires further investigation and validation in different populations. A set of biomarkers that can discriminate between active TB (ATB) and latent TB infection (LTBI) remains elusive.

Methods

In the current study, we organized two retrospective cohorts and one prospective cohort to investigate the immune responses at different clinical stages of TB infection, as determined by candidate cytokine biomarkers detected with a multiplex cytokine platform. Using a pre-established diagnostic algorithm, participants were classified as ATB, LTB

SUBMITTER: Wang S 

PROVIDER: S-EPMC6054748 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature