Quantifying the prognostic significance of microRNA-17/17-5P in cancers: a meta-analysis based on published studies.

ABSTRACT:

Objective

The aim of this study was to investigate the prognostic value of mircoRNA-17 and mircoRNA-17-5P (miR-17/17-5P) in patients with cancer.

Materials and methods

We conducted a comprehensive search on published literature following the guidelines of the meta-analysis of observational studies in epidemiology group for design, implementation, and reporting. The methodological qualities for included studies were assessed using the quality in prognosis studies. The pooled hazard ratios (HRs) with 95% CIs for overall survival (OS) and progression-free survival/recurrence-free survival/disease-free survival (PFS/RFS/DFS) were calculated to appraise the associations between miR-17/17-5P expression and cancer prognosis.

Results

A total of 21 studies involving 2099 subje

SUBMITTER: Duan F 

PROVIDER: S-EPMC6054760 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature