Altered community compositions of Proteobacteria in adults with bronchiectasis.

ABSTRACT: Background:Bronchiectasis is a debilitating disease with chronic airway infection. Proteobacteria, the dominant phylum, can be detected with high-throughput sequencing. Objective:To stratify Proteobacteria compositions according to culture findings in bronchiectasis. Patients and methods:We sampled sputum, split for culture and 16srRNA sequencing, from 106 patients with stable bronchiectasis and 17 healthy subjects. Paired sputa from 22 bronchiectasis patients were collected during exacerbations and convalescence. Results:Forty-five, 41, and 20 patients with clinically stable bronchiectasis had isolated Pseudomonas aeruginosa (PA), other potentially pathogenic microorganisms, and commensals at the initial visit, respectively. The PA group (but not other groups) demonstrated significantly g

SUBMITTER: Guan WJ 

PROVIDER: S-EPMC6054765 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature