Genetic analysis reveals candidate genes for activity QTL in the blind Mexican tetra, Astyanax mexicanus.

ABSTRACT: Animal models provide useful tools for exploring the genetic basis of morphological, physiological and behavioral phenotypes. Cave-adapted species are particularly powerful models for a broad array of phenotypic changes with evolutionary, developmental and clinical relevance. Here, we explored the genetic underpinnings of previously characterized differences in locomotor activity patterns between the surface-dwelling and Pachón cave-dwelling populations of Astyanax mexicanus. We identified multiple novel QTL underlying patterns in overall levels of activity (velocity), as well as spatial tank use (time spent near the top or bottom of the tank). Further, we demonstrated that different regions of the genome mediate distinct patterns in velocity and tank usage. We interrogated eight ge

SUBMITTER: Carlson BM 

PROVIDER: S-EPMC6054784 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature