Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery.

ABSTRACT: Injectable hydrogels with tunable physiochemical and biological properties are potential tools for improving neural stem/progenitor cell (NSPC) transplantation to treat central nervous system (CNS) injury and disease. Here, we developed injectable diblock copolypeptide hydrogels (DCH) for NSPC transplantation that contain hydrophilic segments of modified l-methionine (Met). Multiple Met-based DCH were fabricated by post-polymerization modification of Met to various functional derivatives, and incorporation of different amino acid comonomers into hydrophilic segments. Met-based DCH assembled into self-healing hydrogels with concentration and composition dependent mechanical properties. Mechanical properties of non-ionic Met-sulfoxide formulations (DCH_MO) were stable across divers

SUBMITTER: Wollenberg AL 

PROVIDER: S-EPMC6054810 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature