Mitochondrial inefficiency in infants born to overweight African-American mothers.

ABSTRACT:

Background

Currently 20-35% of pregnant women are obese, posing a major health risk for mother and fetus. It is postulated that an abnormal maternal-fetal nutritional environment leads to adverse metabolic programming, resulting in altered substrate metabolism in the offspring and predisposing to risks of obesity and diabetes later in life. Data indicate that oocytes from overweight animals have abnormal mitochondria. We hypothesized that maternal obesity is associated with altered mitochondrial function in healthy neonatal offspring.

Methods

Overweight and obese (body mass index, (BMI) ≥ 25 kg/m², n = 14) and lean (BMI < 25 kg/m², n = 8), African-American pregnant women carrying male fetuses were recruited from the Barnes Jewish Hospital obstetric clin

SUBMITTER: Abraham M 

PROVIDER: S-EPMC6054813 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature