Identification of Human B-1 Helper T Cells With a Th1-Like Memory Phenotype and High Integrin CD49d Expression.

ABSTRACT: Human B-1 cells have been proposed to be CD20⁺CD27⁺CD43⁺CD1c^- B cells found in the umbilical cord and adult peripheral blood, but their regulatory mechanisms have not been well elucidated. Previously, we reported that mouse CD49d^high CD4⁺ T cells could enhance the secretion of natural antibodies by B-1 cells. In this study, we aimed to investigate the presence and helper functions of the human equivalents of murine CD49d^high CD4⁺ T cells. Here, we showed that human CD49d^high CD4⁺ T cells found in the peritoneal cavity (PEC), spleen, and peripheral blood can enhance the production of IgM antibodies by B-1 cells. As revealed in mouse, CD49d^high CD4⁺ T cells were

SUBMITTER: Lee JG 

PROVIDER: S-EPMC6054961 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature