New Insights Into Interactions of Presynaptic Calcium Channel Subtypes and SNARE Proteins in Neurotransmitter Release.

ABSTRACT: Action potential (AP) induces presynaptic membrane depolarization and subsequent opening of Ca²⁺ channels, and then triggers neurotransmitter release at the active zone of presynaptic terminal. Presynaptic Ca²⁺ channels and SNARE proteins (SNAREs) interactions form a large signal transfer complex, which are core components for exocytosis. Ca²⁺ channels serve to regulate the activity of Ca²⁺ channels through direct binding and indirect activation of active zone proteins and SNAREs. The activation of Ca²⁺ channels promotes synaptic vesicle recruitment, docking, priming, fusion and neurotransmission release. Intracellular calcium increase is a key step for the initiation of vesicle fusion. Various voltage-gated calcium channel (VGCC) subt

SUBMITTER: He R 

PROVIDER: S-EPMC6054978 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature