Modeling of Myotonic Dystrophy Cardiac Phenotypes in Drosophila.

ABSTRACT: After respiratory distress, cardiac dysfunction is the second most common cause of fatality associated with the myotonic dystrophy (DM) disease. Despite the prevalance of heart failure in DM, physiopathological studies on heart symptoms have been relatively scarce because few murine models faithfully reproduce the cardiac disease. Consequently, only a small number of candidate compounds have been evaluated in this specific phenotype. To help cover this gap Drosophila combines the amenability of its invertebrate genetics with the possibility of quickly acquiring physiological parameters suitable for meaningful comparisons with vertebrate animal models and humans. Here we review available descriptions of cardiac disease in DM type 1 and type 2, and three recent papers reporting the ca

SUBMITTER: Chakraborty M 

PROVIDER: S-EPMC6054993 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature