Identification, classification, and signal amplification capabilities of high-turnover gas binding hosts in ultra-sensitive NMR.

ABSTRACT: Nuclear Magnetic Resonance (NMR) can be a powerful tool for investigating exchange kinetics of host-guest interactions in solution. Beyond conventional direct NMR detection, radiofrequency (RF) saturation transfer can be used to enhance the study of such chemical exchange or to enable signal amplification from a dilute host. However, systems that are both dilute and labile (fast dissociation/re-association) impose specific challenges to direct as well as saturation transfer detection. Here we investigate host-guest systems under previously inaccessible conditions using saturation transfer techniques in combination with hyperpolarized nuclei and quantitative evaluation under different RF exposure. We further use that information to illustrate the consequences for signal amplification capabi

SUBMITTER: Kunth M 

PROVIDER: S-EPMC6055117 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature