Chromatin organization by an interplay of loop extrusion and compartmental segregation.

ABSTRACT: Mammalian chromatin is spatially organized at many scales showing two prominent features in interphase: (i) alternating regions (1-10 Mb) of active and inactive chromatin that spatially segregate into different compartments, and (ii) domains (<1 Mb), that is, regions that preferentially interact internally [topologically associating domains (TADs)] and are central to gene regulation. There is growing evidence that TADs are formed by active extrusion of chromatin loops by cohesin, whereas compartmentalization is established according to local chromatin states. Here, we use polymer simulations to examine how loop extrusion and compartmental segregation work collectively and potentially interfere in shaping global chromosome organization. A model with differential attraction bet

SUBMITTER: Nuebler J 

PROVIDER: S-EPMC6055145 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature