Quorum sensing and iron regulate a two-for-one siderophore gene cluster in Vibrio harveyi.

ABSTRACT: The secretion of small Fe-binding molecules called siderophores is an important microbial strategy for survival in Fe-limited environments. Siderophore production is often regulated by quorum sensing (QS), a microbial counting technique that allows organisms to alter gene expression based on cell density. However, the identity and quantities of siderophores produced under QS regulation are rarely studied in the context of their roles in Fe uptake. We investigated the link between QS, siderophores, and Fe uptake in the model marine organism Vibrio harveyi where QS is thought to repress siderophore production. We find that V. harveyi uses a single QS- and Fe-repressed gene cluster to produce both cell-associated siderophores (amphiphilic enterobactins) as well as several relate

SUBMITTER: McRose DL 

PROVIDER: S-EPMC6055174 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature