Ontology highlight
ABSTRACT:
SUBMITTER: Miglianico M
PROVIDER: S-EPMC6055183 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20180702 29
Isoxazolines are oral insecticidal drugs currently licensed for ectoparasite control in companion animals. Here we propose their use in humans for the reduction of vector-borne disease incidence. Fluralaner and afoxolaner rapidly killed <i>Anopheles</i>, <i>Aedes</i>, and <i>Culex</i> mosquitoes and <i>Phlebotomus</i> sand flies after feeding on a drug-supplemented blood meal, with IC<sub>50</sub> values ranging from 33 to 575 nM, and were fully active against strains with preexisting resistance ...[more]