Subsystem organization of axonal connections within and between the right and left cerebral cortex and cerebral nuclei (endbrain).

ABSTRACT: The endbrain (telencephalon) is at the rostral end of the central nervous system and is primarily responsible for supporting cognition and affect. Structurally, it consists of right and left cerebral hemispheres, each parceled into multiple cortical and nuclear gray matter regions. The global network organization of axonal macroconnections between the 244 regions forming the endbrain was analyzed with a multiresolution consensus clustering (MRCC) method that provides a hierarchical description of community clustering (modules or subsystems) within the network. Experimental evidence was collated from the neuroanatomical literature for the existence of 10,002 of a possible 59,292 connections within the network, and they cluster into four top-level subsystems and 60 bottom-level subsystems ar

SUBMITTER: Swanson LW 

PROVIDER: S-EPMC6055193 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature