Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC6055231 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Wang Lu L Zhao Zibo Z Ozark Patrick A PA Fantini Damiano D Marshall Stacy A SA Rendleman Emily J EJ Cozzolino Kira A KA Louis Nundia N He Xingyao X Morgan Marc A MA Takahashi Yoh-Hei YH Collings Clayton K CK Smith Edwin R ER Ntziachristos Panagiotis P Savas Jeffrey N JN Zou Lihua L Hashizume Rintaro R Meeks Joshua J JJ Shilatifard Ali A
Nature medicine 20180521 6
The lysine methyltransferase KMT2C (also known as MLL3), a subunit of the COMPASS complex, implements monomethylation of Lys4 on histone H3 (H3K4) at gene enhancers. KMT2C (hereafter referred to as MLL3) frequently incurs point mutations across a range of human tumor types, but precisely how these lesions alter MLL3 function and contribute to oncogenesis is unclear. Here we report a cancer mutational hotspot in MLL3 within the region encoding its plant homeodomain (PHD) repeats and demonstrate t ...[more]