Wnt-Responsive Odontoblasts Secrete New Dentin after Superficial Tooth Injury.

ABSTRACT: The objective of our experiments was to identify new therapeutic strategies to stimulate dentin formation in an adult tooth. To address this objective, we evaluated dentin production in 2 acute trauma models: one involving a pulp exposure and the other involving a superficial dentin injury. Molecular, cellular, and histologic analyses revealed that in response to a severe injury, where the pulp is exposed to the oral cavity, cell death is rampant and the repair response initiates from surviving pulp cells and, to a lesser extent, surviving odontoblasts. When an injury is superficial, as in the case of a dentin injury model, then disturbances are largely confined to pulp tissue immediately underneath the damaged dentin tubules. We found that the pulp remained vital and innervated; primary o

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC6055255 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature