Factor V levels and risk of venous thrombosis: The MEGA case-control study.

ABSTRACT:

Background

Blood coagulation levels are associated with risk of venous thrombosis (VT). The role of factor (F)V is ambiguous since it plays a dual role in coagulation: it has a procoagulant role when it serves as a cofactor for the activation of thrombin and it has an anticoagulant role by enhancing the inactivation of activated FVIII.

Objectives

To elucidate the association of FV levels with risk of VT.

Patients/methods

We analyzed FV antigen levels in 2377 patients with VT and 2943 controls from the MEGA study. FV levels were categorized according using the 1st, 2.5th, 5th, 10th, 25th, 50th, 75th, 90th, and 95th percentiles of FV levels in controls as cut-off points. Odds ratios (ORs) were estimated using logistic regression models and adjusted for age and sex, live

SUBMITTER: Rietveld IM 

PROVIDER: S-EPMC6055494 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature