Perioperative interruption of direct oral anticoagulants in patients with atrial fibrillation: A systematic review and meta-analysis.

ABSTRACT:

Background

Patients with atrial fibrillation (AF) frequently undergo invasive procedures that require temporary interruption of anticoagulation. There is little evidence to guide the perioperative interruption of direct oral anticoagulants (DOACs).

Methods

A systematic literature search including studies that evaluated the perioperative interruption of DOACs for non-emergent invasive procedures in patients with AF was performed. The primary outcomes of interest were the 30-day risk of thromboembolic events and major bleeding. Secondary outcomes of interest included the 30-day risk of minor bleeding and overall mortality. The systematic review protocol and search strategy were registered online (PROSPERO January 27th 2017:CRD42017056124).

Results

A total of 8 publicati

SUBMITTER: Shaw JR 

PROVIDER: S-EPMC6055497 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature