Effects of daily aspirin on cancer incidence and mortality in the elderly Japanese.

ABSTRACT:

Background

Long-term follow-up of studies to investigate preventive effects of aspirin on arterial thrombosis indicate that aspirin reduces the incidence and mortality of some cancers in Western populations.

Objectives

To explore the effects of aspirin on cancer incidence and mortality in the elderly Japanese.

Patients/methods

Patients aged 60 to 85 years, presenting with hypertension, dyslipidemia, or diabetes mellitus (n = 14 601, 7297 in the aspirin group and 7304 in the no-aspirin group) participated the Japanese Primary Prevention Project (JPPP), a multicenter, open-label, randomized, parallel-group trial. A subanalysis of JPPP was performed to analyze the incidence of newly diagnosed cancer and death related to cancer.

Results

The cumulative incidence of

SUBMITTER: Yokoyama K 

PROVIDER: S-EPMC6055501 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature