HBV-Associated Acute Liver Failure After Immunosuppression and Risk of Death.

ABSTRACT:

Background & aims

Acute liver failure (ALF) caused by hepatitis B virus (HBV) infection can occur after immunosuppressive treatment and be fatal, although it might be preventable. We aimed to characterize the causes, clinical course, and short-term outcomes of HBV-associated ALF after immune-suppressive therapy, compared with patients with HBV-associated ALF without immunosuppression (control subjects).

Methods

We performed a retrospective multicenter study of 156 consecutive patients diagnosed with HBV-associated ALF (22 with a solid or blood malignancy) enrolled in the Acute Liver Failure Study Group registry from January 1998 through April 2015. We collected data on results of serologic and hepatic biochemistry analyses, grade of hepatic encephalopathy, Model for End-Stag

SUBMITTER: Karvellas CJ 

PROVIDER: S-EPMC6055519 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature