Von Willebrand factor multimer quantitation for assessment of cardiac lesion severity and bleeding risk.

ABSTRACT:

Background

von Willebrand factor (VWF) multimer quantitation has been utilized in the assessment of valvular heart disease, however, there is no standardized method for quantitation. We compared three methods of assessment which utilized a normal plasma control.

Methods

We analyzed 476 samples and their control plasma from 368 patients with valvular heart disease, hypertrophic cardiomyopathy, or LVAD therapy, and 27 normal subjects. VWF multimers were assessed as normalized VWF multimer ratios (NMR) of gel bands >15/2-15 (NMR15) or gel bands >10/2-10 (NMR10). Associations of VWF laboratory and multimeric assessments with cardiac lesion severity and acquired bleeding were investigated.

Results

Abnormal multimers were present in 78% of patients with moderate to severe h

SUBMITTER: Austin CO 

PROVIDER: S-EPMC6055563 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature