Positive association between hypertension and urinary bladder cancer: epidemiologic evidence involving 79,236 propensity score-matched individuals.

ABSTRACT:

Introduction

We hypothesized that hypertensive patients harbor a higher risk of urinary bladder (UB) cancer.

Material and methods

We performed a population-based cohort study on adults using a National Health Insurance Research Database (NHIRD) dataset. Hypertension and comparison non-hypertensive (COMP) groups comprising 39,618 patients each were propensity score-matched by age, sex, index date, and medical comorbidities. The outcome was incident UB cancer validated using procedure codes. We constructed multivariable Cox models to derive adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs). Cumulative incidence was compared using a log-rank test.

Results

During a total follow-up duration of 380,525 and 372,020 person-years in the hypertension and COMP gro

SUBMITTER: Kok VC 

PROVIDER: S-EPMC6055751 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature