Early-stage Hodgkin lymphoma in the modern era: simulation modelling to delineate long-term patient outcomes.

ABSTRACT: We developed a novel simulation model integrating multiple data sets to project long-term outcomes with contemporary therapy for early-stage Hodgkin lymphoma (ESHL), namely combined modality therapy (CMT) versus chemotherapy alone (CA) via ¹⁸ F-fluorodeoxyglucose positron emission tomography response-adaption. The model incorporated 3-year progression-free survival (PFS), probability of cure with/without relapse, frequency of severe late effects (LEs), and 35-year probability of LEs. Furthermore, we generated estimates for quality-adjusted life years (QALYs) and unadjusted survival (life years, LY) and used model projections to compare outcomes for CMTversusCA for two index patients. Patient 1: a 25-year-old male with favourable ESHL (stage IA); Patient 2: a 25-year-old female w

SUBMITTER: Parsons SK 

PROVIDER: S-EPMC6055753 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature