Delineation between different components of chronic pain using dimension reduction - an ASL fMRI study in hand osteoarthritis.

ABSTRACT:

Background

Traditional psychometric measures aimed at characterizing the pain experience often show considerable overlap, due to interlinked affective and modulatory processes under central nervous system control. Neuroimaging studies have been employed to investigate this complexity of pain processing, in an attempt to provide a quantifiable, adjunctive description of pain perception. In this exploratory study, we examine psychometric and neuroimaging data from 38 patients with painful osteoarthritis of the carpometacarpal joint. We had two aims: first, to utilize principal component analysis (PCA) as a dimension reduction strategy across multiple self-reported endpoints of pain, cognitive and affective functioning; second, to investigate the relationship between identified dimens

SUBMITTER: Keszthelyi D 

PROVIDER: S-EPMC6055802 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature