Hepatocellular carcinoma-related cyclin D1 is selectively regulated by autophagy degradation system.

ABSTRACT: Dysfunction of degradation machineries causes cancers, including hepatocellular carcinoma (HCC). Overexpression of cyclin D1 in HCC has been reported. We previously reported that autophagy preferentially recruits and degrades the oncogenic microRNA (miR)-224 to prevent HCC. Therefore, in the present study, we attempted to clarify whether cyclin D1 is another oncogenic factor selectively regulated by autophagy in HCC tumorigenesis. Initially, we found an inverse correlation between low autophagic activity and high cyclin D1 expression in tumors of 147 HCC patients and three murine models, and these results taken together revealed a correlation with poor overall survival of HCC patients, indicating the importance of these two events in HCC development. We found that increased autophagic acti

SUBMITTER: Wu SY 

PROVIDER: S-EPMC6055810 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature