Methodology for computing the burden of disease of adverse events following immunization.

ABSTRACT:

Purpose

Composite disease burden measures such as disability-adjusted life-years (DALY) have been widely used to quantify the population-level health impact of disease or injury, but application has been limited for the estimation of the burden of adverse events following immunization. Our objective was to assess the feasibility of adapting the DALY approach for estimating adverse event burden.

Methods

We developed a practical methodological framework, explicitly describing all steps involved: acquisition of relative or absolute risks and background event incidence rates, selection of disability weights and durations, and computation of the years lived with disability (YLD) measure, with appropriate estimation of uncertainty. We present a worked example, in which YLD is comp

SUBMITTER: McDonald SA 

PROVIDER: S-EPMC6055877 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature