Matrix metalloproteinase-7 may serve as a novel biomarker for cervical cancer.

ABSTRACT:

Background

The biological and clinical significance of matrix metalloproteinase-7 (MMP-7) in cervical cancer remains unknown. Here, we investigated the function of MMP-7 in cervical cancer cells and evaluated its clinical significance in both tissues and serum from cervical cancer patients.

Methods

First, we analyzed the expression of MMP-7 in cervical cancer using Oncomine microarray data and examined its expression in cervical tissues by quantitative real-time polymerase chain reaction and Western blotting. Second, we utilized gene silencing to explore the role of MMP-7 in cells. Finally, we examined the MMP-7 levels in patients with cervical cancer and normal serum by enzyme-linked immunosorbent assay. Moreover, we further investigated the relationship between MMP-7 expre

SUBMITTER: Zhu L 

PROVIDER: S-EPMC6055895 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature