Computational Analysis of Neonatal Mouse Ultrasonic Vocalization.

ABSTRACT: Neonatal vocalization is structurally altered in mouse models of autism spectrum disorder (ASD). Our published data showed that pup vocalization, under conditions of maternal separation, contains sequences whose alterations in a genetic mouse model of ASD impair social communication between pups and mothers. We describe details of a method which reveals the statistical structure of call sequences that are functionally critical for optimal maternal care. Entropy analysis determines the degree of non-random call sequencing. A Markov model determines the actual call sequences used by pups. Sparse partial least squares discriminant analysis (sPLS-DA) identifies call sequences that differentiate groups and reveals the degrees of individual variability in call sequences between groups. These thr

SUBMITTER: O Broin P 

PROVIDER: S-EPMC6055925 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature