Obesity-induced changes in lipid mediators persist after weight loss.

ABSTRACT:

Background

Obesity induces significant changes in lipid mediators, however, the extent to which these changes persist after weight loss has not been investigated.

Subjects/methods

We fed C57BL6 mice a high-fat diet to generate obesity and then switched the diet to a lower-fat diet to induce weight loss. We performed a comprehensive metabolic profiling of lipid mediators including oxylipins, endocannabinoids, sphingosines and ceramides in key metabolic tissues (including adipose, liver, muscle and hypothalamus) and plasma.

Results

We found that changes induced by obesity were largely reversible in most metabolic tissues but the adipose tissue retained a persistent obese metabolic signature. Prostaglandin signaling was perturbed in the obese state and lasting increases

SUBMITTER: Hernandez-Carretero A 

PROVIDER: S-EPMC6055936 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature