Neuronal surface and glutamic acid decarboxylase autoantibodies in Nonparaneoplastic stiff person syndrome.

ABSTRACT:

Importance

High titers of autoantibodies to glutamic acid decarboxylase (GAD) are well documented in association with stiff person syndrome (SPS). Glutamic acid decarboxylase is the rate-limiting enzyme in the synthesis of γ-aminobutyric acid (GABA), and impaired function of GABAergic neurons has been implicated in the pathogenesis of SPS. Autoantibodies to GAD might be the causative agent or a disease marker.

Objective

To investigate the characteristics and potential pathogenicity of GAD autoantibodies in patients with SPS and related disorders.

Design

Retrospective cohort study and laboratory investigation.

Setting

Weatherall Institute of Molecular Medicine, University of Oxford.

Participants

Twenty-five patients with SPS and related conditions identif

SUBMITTER: Chang T 

PROVIDER: S-EPMC6055982 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature