The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy.

ABSTRACT: Cancer chronotherapy, treatment at specific times during circadian rhythms, endeavors to optimize anti-tumor effects and to lower toxicity. However, comprehensive characterization of clock genes and their clinical relevance in cancer is lacking. We systematically characterized the alterations of clock genes across 32 cancer types by analyzing data from The Cancer Genome Atlas, Cancer Therapeutics Response Portal, and The Genomics of Drug Sensitivity in Cancer databases. Expression alterations of clock genes are associated with key oncogenic pathways, patient survival, tumor stage, and subtype in multiple cancer types. Correlations between expression of clock genes and of other genes in the genome were altered in cancerous versus normal tissues. We identified interactions between clock gene

SUBMITTER: Ye Y 

PROVIDER: S-EPMC6056007 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature