Activating natural killer (NK) cytotoxicity of canine CD5^-CD21^- cells requires low surface CD5 density NK cells.

ABSTRACT: Natural killer (NK) cells play a crucial role in regulating immune functions. Few studies have characterized canine NK cells. We previously demonstrated that canine peripheral blood lymphocytes (PBLs) with a low surface CD5 density (CD5lo) are considered a critical NK population. Natural killer cells in most mammals do not express T-cell markers, but canine CD5lo cells express surface molecules, such as CD3 T-cell receptors. These features make canines unique models for the study of comparative immunology in NK cells. In this study, we discovered that CD5lo and CD21 double-negative (CD5lo-ne/CD2^-) cells were originally low in NK cytotoxicity and their NK cytotoxicity was highly activated when co-cultured with CD5lo NK cells. The cytotoxicity was not activated when co-cultured wi

SUBMITTER: Lin CS 

PROVIDER: S-EPMC6056148 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature