Kidney Dysfunction After Vascularized Composite Allotransplantation.

ABSTRACT:

Background

Kidney dysfunction is a major complication after nonrenal solid organ transplants. Transplantation of vascularized composite allografts (VCA) has yielded successful midterm outcomes despite high rates of acute rejection and greater requirements of immunosuppression. Whether this translates in higher risks of kidney complications is unknown.

Methods

Ninety-nine recipients of facial or extremity transplants from the Brigham and Women's Hospital (BWH) and the International Registry on Hand and Composite Tissue Transplantation (IR) were reviewed. We assessed immunosuppression, markers of renal function over time, as well as pretransplant and posttransplant renal risk factors.

Results

Data were obtained from 10 patients from BWH (age at transplant, 42.5 ± 13.8 y

SUBMITTER: Krezdorn N 

PROVIDER: S-EPMC6056276 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature