Poor Prognostic Implication of ASXL1 Mutations in Korean Patients With Chronic Myelomonocytic Leukemia.

ABSTRACT:

Background

Molecular genetic abnormalities are observed in over 90% of chronic myelomonocytic leukemia (CMML) cases. Recently, several studies have demonstrated the negative prognostic impact of ASXL1 mutations in CMML patients. We evaluated the prognostic impact of ASXL1 mutations and compared five CMML prognostic models in Korean patients with CMML.

Methods

We analyzed data from 36 of 57 patients diagnosed as having CMML from January 2000 to March 2016. ASXL1 mutation analysis was performed by direct sequencing, and the clinical and laboratory features of patients were compared according to ASXL1 mutation status.

Results

ASXL1 mutations were detected in 18 patients (50%). There were no significant differences between the clinical and laboratory characteristics of AS

SUBMITTER: Kim HY 

PROVIDER: S-EPMC6056400 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature