Volatile compounds emission from teratogenic human pluripotent stem cells observed during their differentiation in vivo.

ABSTRACT: Several investigations point out that the volatile fraction of metabolites, often called volatilome, might signal the difference processes occurring in living beings, both in vitro and in vivo. These studies have been recently applied to stem cells biology, and preliminary results show that the composition of the volatilome of stem cells in vitro changes along the differentiation processes leading from pluripotency to full differentiation. The identification of pluripotent stem cells is of great importance to improve safety in regenerative medicine avoiding the formation of teratomas. In this paper, we applied gas chromatography and gas sensor array to the study of the volatilome released by mice transplanted with human induced pluripotent stem cells (hiPSCs) or embryoid bodies (EBs) deriv

SUBMITTER: Capuano R 

PROVIDER: S-EPMC6056464 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature