The effect of adipose-derived stem cell sheets and CTGF on early flexor tendon healing in a canine model.

ABSTRACT: Intrasynovial tendon injuries are among the most challenging in orthopedics. Despite significant improvements in operative and rehabilitation methods, functional outcomes continue to be limited by adhesions, gap formation, and rupture. Adhesions result from excessive inflammation, whereas tendon gapping and rupture result from inflammation-induced matrix degradation and insufficient regeneration. Therefore, this study used a combined treatment approach to modulate inflammation with adipose-derived mesenchymal stromal cells (ASCs) while stimulating tendon regeneration with connective tissue growth factor (CTGF). ASCs were applied to the repair surface via cell sheets and CTGF was delivered to the repair center via porous sutures. The effect of the combined treatment was assessed fourteen da

SUBMITTER: Shen H 

PROVIDER: S-EPMC6056475 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature