Hydrolysis of Extracellular Pyrophosphate increases in post-hemodialysis plasma.

ABSTRACT: Vascular calcification (VC) is associated with significant morbidity and mortality of dialysis patients. Previous studies showed an association between loss of plasma pyrophosphate and VC. Moreover, loss of pyrophosphate occurs during dialysis in this population, suggesting that therapeutic approaches that prevent reduction of plasma pyrophosphate levels during dialysis could improve the quality of life of dialysis patients. This study found that pyrophosphate hydrolysis was 51% higher in post- than pre-dialysis plasma. Dialysis sessions modified the kinetic behavior of alkaline phosphatase, increasing its V_max and reducing its K_m, probably due to the elimination of uremic toxins during dialysis. At least 75% of alkaline phosphatase activity in human plasma was found

SUBMITTER: Azpiazu D 

PROVIDER: S-EPMC6056505 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature