Regulation of biomass degradation by alternative σ factors in cellulolytic clostridia.

ABSTRACT: Bacteria can adjust their genetic programs via alternative σ factors to face new environmental pressures. Here, we analyzed a unique set of paralogous alternative σ factors, termed σ^Is, which fine-tune the regulation of one of the most intricate cellulolytic systems in nature, the bacterial cellulosome, that is involved in degradation of environmental polysaccharides. We combined bioinformatics with experiments to decipher the regulatory networks of five σ^Is in Clostridium thermocellum, the epitome of cellulolytic microorganisms, and one σ^I in Pseudobacteroides cellulosolvens which produces the cellulosomal system with the greatest known complexity. Despite high homology between different σ^Is, our data suggest limited cross-talk among them. Remar

SUBMITTER: Ortiz de Ora L 

PROVIDER: S-EPMC6056542 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature