Reaction and diffusion thermodynamics explain optimal temperatures of biochemical reactions.

ABSTRACT: Ubiquitous declines in biochemical reaction rates above optimal temperatures (T_opt) are normally attributed to enzyme state changes, but such mechanisms appear inadequate to explain pervasive T_opt well below enzyme deactivation temperatures (T_den). Here, a meta-analysis of 92 experimental studies shows that product formation responds twice as strongly to increased temperature than diffusion or transport. This response difference has multiple consequences for biochemical reactions, such as potential shifts in the factors limiting reactions as temperature increases and reaction-diffusion dynamics that predict potential product inhibition and limitation of the reaction by entropy production at temperatures below T_den. Maximizing entropy production b

SUBMITTER: Ritchie ME 

PROVIDER: S-EPMC6056565 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature