Pan-Cancer Analysis Reveals the Functional Importance of Protein Lysine Modification in Cancer Development.

ABSTRACT: Large-scale tumor genome sequencing projects have revealed a complex landscape of genomic mutations in multiple cancer types. A major goal of these projects is to characterize somatic mutations and discover cancer drivers, thereby providing important clues to uncover diagnostic or therapeutic targets for clinical treatment. However, distinguishing only a few somatic mutations from the majority of passenger mutations is still a major challenge facing the biological community. Fortunately, combining other functional features with mutations to predict cancer driver genes is an effective approach to solve the above problem. Protein lysine modifications are an important functional feature that regulates the development of cancer. Therefore, in this work, we have systematically analyzed somatic

SUBMITTER: Chen L 

PROVIDER: S-EPMC6056651 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature