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When Bacterial Culture Fails, Metagenomics Can Help: A Case of Chronic Hepatic Brucelloma Assessed by Next-Generation Sequencing.

ABSTRACT: Here, we sequenced DNA extracted from a necrotic hepatic lesion from a patient with suspected chronic hepatic brucelloma but negative culture results. Although most of the taxonomically classified sequencing reads corresponded to human genome sequences, our data suggest that whole-metagenome shotgun sequencing may be used together with other tests to strengthen the diagnosis of hepatic brucelloma.

SUBMITTER: Lazarevic V 

PROVIDER: S-EPMC6056729 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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When Bacterial Culture Fails, Metagenomics Can Help: A Case of Chronic Hepatic Brucelloma Assessed by Next-Generation Sequencing.

Lazarevic Vladimir V   Gaïa Nadia N   Girard Myriam M   Leo Stefano S   Cherkaoui Abdessalam A   Renzi Gesuele G   Emonet Stéphane S   Jamme Sharon S   Ruppé Etienne E   Vijgen Sandrine S   Rubbia-Brandt Laura L   Toso Christian C   Schrenzel Jacques J  

Frontiers in microbiology 20180717

Here, we sequenced DNA extracted from a necrotic hepatic lesion from a patient with suspected chronic hepatic brucelloma but negative culture results. Although most of the taxonomically classified sequencing reads corresponded to human genome sequences, our data suggest that whole-metagenome shotgun sequencing may be used together with other tests to strengthen the diagnosis of hepatic brucelloma. ...[more]

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