Opportunities and Challenges for Genetic Studies of End-Stage Renal Disease in Canada.

ABSTRACT:

Purpose of review

Genetic testing can improve diagnostic precision in some patients with end-stage renal disease (ESRD) providing the potential for targeted therapy and improved patient outcomes. We sought to describe the genetic architecture of ESRD and Canadian data sources available for further genetic investigation into ESRD.

Sources of information

We performed PubMed searches of English, peer-reviewed articles using keywords "chronic kidney disease," "ESRD," "genetics," "sequencing," and "administrative databases," and searched for nephrology-related Mendelian diseases on the Online Mendelian Inheritance in Man database.

Methods

In this narrative review, we discuss our evolving understanding of the genetic architecture of kidney disease and ESRD, the risks and be

SUBMITTER: Kalatharan V 

PROVIDER: S-EPMC6056781 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature